ABSTRACT
Sex hormones and chronic respiratory diseases play a role in the pathogenesis and the management of Covid-19 infection. Present research tries to shed light on the role of sex hormones, bronchial asthma and lung cancer on the severity of Covid-19 infection and the resulting mortality rate. This study included a follow-up of the health status of 85 patients infected with Covid-19, and all the patients previously diagnosed had hereditary respiratory diseases (bronchial asthma (64) and lung cancer (21)). The serum level of progesterone and testosterone and the stages of lung cancer development were measured in the laboratories of Diwaniyah Teaching Hospital. After conducting medical examinations, computed tomography and x-rays, the severity of Covid-19 infection was classified according to the WHO to moderate, severe and critical infection. The current results showed that most of the hospitalized cases were males (65%) with a death rate (18%), so bronchial asthma was associated with the death rate in males (70% of dead males), followed by postmenopausal (POM) women (66.7% of the dead woman), while pre-menopausal (PRM) women had the highest cure rate (100%). The results of the study showed that the rise in the mean of progesterone in PRM (13.55 ng/ml) was associated with moderate symptoms of Covid-19, while the increased testosterone in males and POM (1018 ng/dL and 67.3 ng/dL, respectively) was associated with an increase in the severity of the infection. In conclusion, asthma and high testosterone directly affected the increase in the severity of Covid-19 and the high mortality rate among the Corona sufferers. While advanced lung cancer had a clear role in that, at the same time, progesterone appeared as a protective factor in young women. © 2022 by the authors.
ABSTRACT
Background: Reports revealed rising levels of skin diseases secondary to protective equipment use. Healthcare providers who are working day and night during the pandemic of COVID-19 are more susceptible to the damage of the skin. There is scarce published data about the incidence of skin disorders secondary to protective equipment use during the COVID-19 pandemic and what factors are associated in Saudi Arabia. Aim: Assessing the potential skin damage as a result of personal protection equipment (PPE) and intensive hygiene measures for healthcare providers during COVID-19 pandemic in Aseer region. Methods: This study a cross-sectional questionnaire-based study done in Aseer region from January to October 2021. Personal data and related to history of skin disease, practices toward personal protective equipment, and new skin damage was collected and analyzed. Independent t-test and chi-square test was used to determine factors associated with the incidence of new skin damage during the COVID-19 pandemic. Results: Total of 214 participants was included in the study. (47.7%) of the participants reported experiencing new skin damage during the COVID-19 pandemic, while 112 (52.3%) of the participants did not. Age, having a history of chronic skin disease, and number of worn gloves layers were all significantly associated with the incidence of skin damage during COVID-19 pandemic. Conclusion: The considerable rate of new skin damage during the COVID-19 pandemic makes it essential to take action and start rising awareness toward this topic among health-care workers as well as teaching them how to prevent the incidence of new skin damage.